About
RNAble is developing novel compounds that alter RNA stability through modulation of RNA epitranscriptomics for the treatment of specific cancers and rare genetic diseases with nonsense mutations. RNA transcripts undergo modifications that are recognized by specific RNA binding proteins dictating their stability. Prof. Rotem Karni, RNAble inventor, discovered that targeting components of the RNA epitranscriptomic machinery with small molecules resulted in the stabilization of several RNAs, including unstable nonsense mutated transcripts which are degraded by the nonsense-mediated decay machinery (NMD). This opens the possibility to restore the expression of mutated genes essential in rare diseases and suppress the growth of specific cancers.
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Frequently Asked Questions
What does RNAble do?
RNAble is developing novel compounds that alter RNA stability through modulation of RNA epitranscriptomics for the treatment of specific cancers and rare genetic diseases with nonsense mutations. RNA transcripts undergo modifications that are recognized by specific RNA binding proteins dictating their stability. Prof. Rotem Karni, RNAble inventor, discovered that targeting components of the RNA epitranscriptomic machinery with small molecules resulted in the stabilization of several RNAs, includ…
When was RNAble founded?
RNAble was founded in 2021.
What industry does RNAble operate in?
RNAble operates in Life Sciences, RNA-Targeting, Oncology, RNA.
How many employees does RNAble have?
RNAble has approximately 5 people on record.