The future of drug discovery and development hinges on a fundamental shift in how science is conducted, moving from artisanal processes to a more industrialized, data-driven approach. This was the central thesis explored by Sajith Wickramasekara, co-founder and CEO of Benchling, in a recent interview with Sarah Guo on the "No Priors" podcast. Wickramasekara, whose company provides the central system of record for biotech R&D, offered a sharp analysis of the biotech industry's current state, the transformative potential of AI agents, and the unique challenges of merging scientific and software cultures.
Wickramasekara, a software engineer who transitioned into biology, started Benchling 13 years ago out of frustration with the archaic tools available to scientists. He observed that while software developers enjoyed sophisticated tools for coding and collaboration, biologists were still largely relying on paper notebooks and disparate spreadsheets. This stark contrast led him to build software that helps scientists design molecules, plan and run experiments, organize and analyze data, and share findings with colleagues. Today, Benchling powers over 1,300 biotech and pharma companies, including industry giants like Moderna and Eli Lilly, as well as cutting-edge AI biotech startups like Isomorphic Labs.
The drug development process, Wickramasekara emphasizes, is incredibly long, complex, and expensive. It involves thousands of steps, from identifying a biologically meaningful target to designing, optimizing, and testing molecules in various stages, eventually leading to clinical trials and manufacturing. This entire journey, which can take seven to ten years and cost over $2 billion, is fraught with high failure rates, often very late in the process. He likens the recent downturn in biotech to a "dot-com bust," driven by an influx of generalist money during the COVID-19 mRNA vaccine boom, coupled with rising interest rates, tariffs, regulatory uncertainty, and the competitive rise of Chinese biotech.
A core insight from Wickramasekara's commentary is that the biotech industry is currently in a phase where "speed and cost" are paramount. People demand more drugs, and they want them cheaper. This urgency is being met, in part, by Chinese biotech companies, which are rapidly developing and bringing molecules to early-stage clinical trials faster and more affordably, even in new modalities like gene editing and cell therapies. This has led major Western pharmaceutical companies to acquire molecules from Chinese biotechs, a trend that underscores the competitive pressure on American biotech to innovate more efficiently.
Wickramasekara points out that a significant portion of the high cost and inefficiency in drug development stems from its "artisanal" nature. The industry often operates like a series of one-time games, with companies focused on surviving long enough to show clinical success before being acquired by larger pharma. This discourages building for long-term scalability and durability. This is where AI’s role becomes critical. Benchling AI aims to provide "more shots on goal, faster, cheaper," by enabling scientists to make better molecules and bring them to the clinic more quickly and safely.
Benchling AI focuses on two major components: simulation tools and autonomous agents. The simulation tools integrate open-source, proprietary, and internal models, making them accessible to wet lab scientists without advanced computational skills. The results are directly linked to existing Benchling data, enabling scientists to ask complex questions that previously would have taken months, now in mere hours. For instance, one client used Benchling’s deep research capability to analyze historical mouse studies and avoid re-investigating models that had already been explored, saving significant time and resources. The autonomous agents, similar to those developed by Anthropic, are designed to automate various scientific tasks, from generating reports and answering questions to composing experiments using voice and vision interfaces.
Wickramasekara is bullish on the "augmentation model" for AI in biotech, rather than full automation. He believes that while AI will significantly enhance scientific capabilities, human accountability, critical thinking, and the ability to interpret complex biological nuances will remain indispensable. He draws a parallel to radiology, where AI has augmented, not replaced, radiologists. The immediate future, over the next one to two years, will see a surge in "co-pilot" models, where AI assists scientists in making better, faster decisions, compressing the drug development timeline from seven to ten years down to two to three.
Another crucial insight is the importance of data in biotech. For a field so reliant on data, there are surprisingly few transactions of scientific data outside of clinical trials. This is largely due to a lack of trust in data quality and format. Benchling aims to address this by providing a structured data model that makes scientific data reusable and trustworthy, effectively "unlocking memory" for R&D organizations. This structured data is essential for training the predictive models that will drive the next wave of innovation.
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The conversation also touched on the culture of biotech. Wickramasekara, reflecting on Benchling’s 13-year journey, highlighted the initial challenge of evangelizing the concept of bringing science online. He found that while every customer claimed their work was unique, they almost universally desired the same core functionalities. This underscores the need for standardized, high-quality software tools that can serve a broad scientific community. He emphasizes the importance of founders maintaining deep engagement with customers, understanding their evolving needs, and being willing to "look stupid" in the pursuit of genuine solutions. This customer-centricity, coupled with a belief in the transformative power of technology, is what he believes will drive the industry forward.
The interview paints a picture of a biotech landscape on the cusp of profound change. AI, integrated through platforms like Benchling, is poised to address the industry's long-standing challenges of cost, speed, and efficiency. This will not only accelerate the development of new medicines but also democratize access to advanced scientific tools, ultimately benefiting humanity by delivering more effective drugs, faster and cheaper.
