“I think the frontier right now is scientific taste,” remarked Andrew White, co-founder of Future House and Edison Scientific, during his interview on the Latent Space Network’s new AI for Science podcast. White, alongside hosts RJ Honicky and Brandon Anderson, offered sharp commentary on the rapid shift from traditional computational methods to advanced AI agents in scientific discovery, a transformation that has moved from the esoteric corners of academia to the halls of the White House. This frontier, he argues, is less about raw intelligence and more about replicating the nuanced, often subjective human ability to discern which hypotheses are truly valuable and actionable.
Andrew White spoke with Brandon Anderson and RJ Honicky about his journey from a tenured professor studying molecular dynamics and biomaterials to a founder leading the charge in automating science. The conversation centered on the development and implications of his autonomous research system, Cosmos, highlighting the critical roles of world models, agent loops, and the surprisingly difficult challenge of quantifying scientific value.
White’s background provided immediate context for the seismic shifts occurring in the scientific community. He described his early work on molecular dynamics (MD), noting how the traditional, physics-based approach to protein folding, exemplified by the massive hardware investment of D. E. Shaw Research, was suddenly rendered obsolete by DeepMind’s machine learning breakthrough, AlphaFold. “I always thought that protein folding would be solved by them, but it would require a special machine... and when AlphaFold came out and it's like you can do it in Google Colab, or on a GPU on your desktop, it was so mind-blowing. The fact that it was solved and on your desktop you can do it was just completely floored, changed everything.” This "Bitter Lesson for Biology," where brute-force simulation was superseded by data-driven learning, underscored White’s decision to pivot his career toward AI.
The initial steps into applied AI led to ChemCrow, the Large Language Model (LLM) agent that combined GPT-4 with cloud lab automation tools. ChemCrow’s capabilities immediately triggered a storm of anxiety regarding dual-use risk, leading to White House briefings and meetings with three-letter agencies asking existential questions like, “how does this change breakout time for nuclear weapons research?” This experience highlighted the immense power of integrating LLMs with real-world tools, but also the critical need for safety and responsible deployment.
This led directly to the core innovation behind Cosmos: an end-to-end scientific agent designed to accelerate the scientific method itself. Cosmos operates on a loop of hypothesis generation, literature search, experiment design, data analysis, and world model updating. White explained that early attempts to train the agents using standard reinforcement learning from human feedback (RLHF) on hypotheses failed because "humans pay attention to tone, actionability, and specific facts, not 'if this hypothesis is true/false, how does it change the world?'" The breakthrough was incorporating actual data analysis into the loop, allowing the model to refine its "scientific taste" based on real-world experimental results and the subsequent engagement signals (like clicks or downloads) from human scientists.
The world model itself, according to White, is essentially a "distilled memory system, like a Git repo for scientific knowledge," which accumulates and organizes findings to inform future hypotheses. This emphasis on iterative, real-world feedback loops is crucial because, as White noted, even expert human scientists often disagree on which research paths are most promising. He cited results showing that humans only agree on the interpretation of complex data analysis 52% to 70% of the time, revealing a significant "human bias" or "disagreement level" that AI, through rapid iteration and verifiable data analysis, can potentially transcend. The future, therefore, lies not just in smarter models, but in systems capable of rapidly testing and refining hypotheses in a constrained, data-rich environment, ultimately pushing the boundaries of discovery faster than human intuition alone could allow.
