# Sylentis

**Source:** https://www.startuphub.ai/startups/sylentis
**Profile type:** Startup

> Ophthalmic pharmaceutical company developing novel treatments for ocular diseases.

## About

Sylentis is a biopharmaceutical company specializing in ocular gene silencing therapies using RNA interference (RNAi) technology. They develop siRNA compounds to reduce the production of disease-causing proteins, with a current focus on treating dry eye syndrome and age-related macular degeneration. Sylentis also offers siRNA development services and collaborates with other companies on oligonucleotide-based drug development.

## Key facts

- **Slug:** sylentis
- **Website:** https://www.sylentis.com/
- **Location:** Madrid, Spain
- **Founded:** 2000-01-01
- **Employees:** 61
- **Operating status:** Active
- **Total funding:** $135M
- **Sectors / tags:** Biotech, MedTech, HealthTech, Drug Discovery, Clinical Trials, Ophthalmology
- **Social:**
  - LinkedIn: https://www.linkedin.com/company/sylentis

## Frequently asked

### What does Sylentis do?

Sylentis is a biopharmaceutical company specializing in ocular gene silencing therapies using RNA interference (RNAi) technology. They develop siRNA compounds to reduce the production of disease-causing proteins, with a current focus on treating dry eye syndrome and age-related macular degeneration. Sylentis also offers siRNA development services and collaborates with other companies on oligonucleotide-based drug development.

### What is Sylentis's revenue?

StartupHub estimates Sylentis's annual revenue at $14.4M (range $7.8M to $24.9M, 64% confidence), based on comparable companies in the sector.

### What is Sylentis's valuation?

StartupHub estimates Sylentis's effective valuation at $553.5M (range $337.5M to $810.0M, 10% confidence), based on comparable companies in the sector.

### How much funding has Sylentis raised?

Sylentis has raised a total of $135M in funding. The most recent round on record is Series C.

### Where is Sylentis headquartered?

Sylentis is headquartered in Madrid, Spain.

### When was Sylentis founded?

Sylentis was founded in 2000.

### What industry does Sylentis operate in?

Sylentis operates in Biotech, MedTech, HealthTech, Drug Discovery, Clinical Trials, Ophthalmology.

### How many employees does Sylentis have?

Sylentis has approximately 61 people on record.

## JSON-LD

Structured data aligned with this page's `<script type="application/ld+json">` (included when the profile is server-rendered).

```json
{
  "@context": "https://schema.org",
  "@graph": [
    {
      "@type": "BreadcrumbList",
      "itemListElement": [
        {
          "@type": "ListItem",
          "position": 1,
          "name": "Home",
          "item": "https://www.startuphub.ai"
        },
        {
          "@type": "ListItem",
          "position": 2,
          "name": "Startups",
          "item": "https://www.startuphub.ai/startups"
        },
        {
          "@type": "ListItem",
          "position": 3,
          "name": "Sylentis",
          "item": "https://www.startuphub.ai/startups/sylentis"
        }
      ]
    },
    {
      "@type": "ProfilePage",
      "@id": "https://www.startuphub.ai/startups/sylentis#webpage",
      "url": "https://www.startuphub.ai/startups/sylentis",
      "name": "Sylentis - AI Startup Profile | StartupHub.ai",
      "description": "This is the official profile of Sylentis. Sylentis is a startup founded in 2000, operating in Biotech and MedTech. Ophthalmic pharmaceutical company developing novel treatments for ocular diseases. Headquartered in Madrid, Spain. The company has approximately 61 employees.",
      "dateModified": "2026-05-28T14:11:16.103+00:00",
      "mainEntity": {
        "@id": "https://www.startuphub.ai/startups/sylentis#organization"
      }
    },
    {
      "@type": "Organization",
      "@id": "https://www.startuphub.ai/startups/sylentis#organization",
      "name": "Sylentis",
      "url": "https://www.sylentis.com/",
      "logo": "https://cdn.startuphub.ai/storage/v1/object/public/entity-images/logos/022af6ad-7d94-4d62-b62c-aacd0339021f-square.webp",
      "image": "https://cdn.startuphub.ai/storage/v1/object/public/entity-images/logos/022af6ad-7d94-4d62-b62c-aacd0339021f-square.webp",
      "description": "This is the official profile of Sylentis. Sylentis is a startup founded in 2000, operating in Biotech and MedTech. Ophthalmic pharmaceutical company developing novel treatments for ocular diseases. Headquartered in Madrid, Spain. The company has approximately 61 employees.",
      "sameAs": [
        "https://www.linkedin.com/company/sylentis",
        "https://www.startuphub.ai/startups/sylentis"
      ],
      "foundingDate": "2000-01-01",
      "numberOfEmployees": {
        "@type": "QuantitativeValue",
        "value": 61
      },
      "address": {
        "@type": "PostalAddress",
        "addressLocality": "Madrid",
        "addressCountry": "Spain"
      },
      "knowsAbout": [
        "Biotech",
        "MedTech",
        "HealthTech",
        "Drug Discovery",
        "Clinical Trials",
        "Ophthalmology"
      ]
    },
    {
      "@type": "Product",
      "@id": "https://www.startuphub.ai/startups/sylentis#profile-assessment",
      "name": "Sylentis - StartupHub.ai Profile Assessment",
      "url": "https://www.startuphub.ai/startups/sylentis",
      "image": "https://cdn.startuphub.ai/storage/v1/object/public/entity-images/logos/022af6ad-7d94-4d62-b62c-aacd0339021f-square.webp",
      "category": "Biotech",
      "description": "This is the official profile of Sylentis. Sylentis is a startup founded in 2000, operating in Biotech and MedTech. Ophthalmic pharmaceutical company developing novel treatments for ocular diseases. Headquartered in Madrid, Spain. The company has approximately 61 employees. Agent Readiness score: 32/100. Full audit: https://www.startuphub.ai/startups/sylentis/agent-readiness",
      "brand": {
        "@type": "Brand",
        "name": "Sylentis"
      },
      "review": {
        "@type": "Review",
        "author": {
          "@type": "Organization",
          "name": "StartupHub.ai"
        },
        "datePublished": "2026-05-28",
        "name": "Sylentis - Profile Score 55/100",
        "reviewBody": "This is the official profile of Sylentis. Sylentis is a startup founded in 2000, operating in Biotech and MedTech. Ophthalmic pharmaceutical company developing novel treatments for ocular diseases. Headquartered in Madrid, Spain. The company has approximately 61 employees. Agent Readiness score: 32/100. Full audit: https://www.startuphub.ai/startups/sylentis/agent-readiness",
        "reviewRating": {
          "@type": "Rating",
          "ratingValue": 55,
          "bestRating": 100,
          "worstRating": 0
        }
      }
    }
  ]
}
```