# Jennifer Doudna on CRISPR's Non-Permanent Gene Editing _Jennifer Doudna discusses Scribe Therapeutics' non-permanent gene editing tech, its potential for common diseases, and the role of AI in science._ **Published:** 2026-07-24 **Source:** https://www.startuphub.ai/healthcare/drug-discovery/jennifer-doudna-on-crispr-s-non-permanent-gene-editing --- Jennifer Doudna, co-founder and scientific advisor at Scribe Therapeutics, discussed the company's innovative approach to gene therapy and its recent IPO on Bloomberg Tech. Scribe's lead therapy targets LDL cholesterol reduction with a single treatment, distinguishing itself through a method called "epi-editing." This technique modifies protein production without permanently altering a patient's DNA, a crucial safety feature that Doudna believes will enable broader application for common diseases. CRISPR Gene EditingCore Jennifer Doudna discusses Scribe Therapeutics' non-permanent gene editing technologyFrom the articleThis non-permanent modification is seen as a significant advancement over earlier gene editing approaches, potentially easing regulatory hurdles and increasing patient safety.Epi-Editing MethodContextFrom the article 2 mentionsScribe's lead therapy targets LDL cholesterol reduction with a single treatment, distinguishing itself through a method called "epi-editing." This technique modifies protein production without permanently altering a patient's DNA, a crucial safety feature that Doudna believes will enable broader application for common diseases.AI in Drug DiscoveryContextAI is a tool, not a replacement, for accelerating scientific discoveryFrom the articleWhen asked about the role of artificial intelligence in drug discovery, Doudna shared her perspective, which she had previously discussed with Bloomberg's Emily Chang.Non-Permanent ChangesEffectcrucial safety feature enabling broader application for common diseasesFrom the article 2 mentionsDoudna elaborated on the importance of epi-editing, explaining that it involves making changes to DNA that are not permanent but effectively alter protein production.Scribe Therapeutics IPOOutcomeFrom the article 3 mentionsJennifer Doudna, co-founder and scientific advisor at Scribe Therapeutics, discussed the company's innovative approach to gene therapy and its recent IPO on Bloomberg Tech.allowsTreat Common DiseasesEffectsafely and effectively use this therapy for widespread health issuesFrom the article 2 mentions"We think this is an incredibly important moment in the field because it means we can now use this therapy safely and effectively for common disease," she stated.exampleLDL Cholesterol TargetOutcomeFrom the articleScribe's lead therapy targets LDL cholesterol reduction with a single treatment, distinguishing itself through a method called "epi-editing." This technique modifies protein production without permanently altering a patient's DNA, a crucial safety feature that Doudna believes will enable broader application for common diseases. ## The Significance of Epi-Editing Doudna elaborated on the importance of epi-editing, explaining that it involves making changes to DNA that are not permanent but effectively alter protein production. "We think this is an incredibly important moment in the field because it means we can now use this therapy safely and effectively for common disease," she stated. This non-permanent modification is seen as a significant advancement over earlier gene editing approaches, potentially easing regulatory hurdles and increasing patient safety. The full discussion can be found on **Bloomberg Technology**'s YouTube channel. ![](https://img.youtube.com/vi/5ZnLm5f2vy0/maxresdefault.jpg) Jennifer Doudna: "AI Doesn't Replace Scientists", from Bloomberg Technology ## Scribe Therapeutics' Clinical Stage and IPO Scribe Therapeutics is currently a clinical-stage company, with its first indication already in a Phase One trial. Doudna confirmed that the funds raised from the IPO will be instrumental in advancing these therapies and expanding their reach. The company's strategy is built on robust science and a commitment to safety and efficacy, aiming to provide treatments that are both powerful and broadly accessible. ## Patient Behavior and One-Time Treatments The conversation also touched upon the practical implications of Scribe's single-treatment approach, contrasting it with daily medications like statins for heart disease. Doudna highlighted the potential benefit for patients: "I think it's very interesting to think about a way of treating or preventing disease that doesn't require taking a pill every day, that is really effectively a one or few time treatment." This could alleviate the burden of adherence and potential side effects associated with daily medication regimens. ## AI in Drug Discovery: A Tool, Not a Replacement When asked about the role of artificial intelligence in drug discovery, Doudna shared her perspective, which she had previously discussed with Bloomberg's Emily Chang. She acknowledged AI as an "incredible tool" that can accelerate scientific work but stressed that it does not replace human scientists. "We still need innovators. We still need creative people. We still need the new ideas that come out of left field, and we don't see that with AI," Doudna remarked. She views AI as a valuable partner that enhances, rather than supplants, human ingenuity in scientific research. ## Market Reception and Investor Confidence The IPO saw Scribe Therapeutics priced at $15 per share, with indications that it would open around $29. Notably, approximately 75% of the shares were allocated to just 10 investors. Doudna interpreted this strong investor reception as a sign that the market understands the distinctiveness of Scribe's technology, the quality of its team, and its dedication to scientific rigor. "That's what we're seeing, I think, reflected in the marketplace," she concluded. --- Original analysis from [startuphub.ai](https://www.startuphub.ai), the #1 AI startup directory.